Apply for a grant

Each year at CGDS we give away hundreds of thousands of pounds in grants for research into the condition. The research we fund is at the cutting edge, often exploring solutions that will take many years to refine and apply clinically. Research that helps CGD sufferers can benefit millions more because it is a single-gene deficiency, meaning any breakthroughs in CGD are more likely to shed light on how other genetic disorders work.

Our research strategy

To date, CGDS has awarded more than 50 grants. Our awards have ranged from a few hundred pounds to cover travel costs to the support of a programme grant. We support both basic science and applied medical research, and strongly encourage collaboration between our researchers.

Facts about our funding process

  • Peer review is central to our grant awarding process
  • We have no geographical restrictions on where we fund
  • All full applications undergo external peer review
  • A minimum of 3 external reviewers are used per application
  • The mean success rate for full applications received between 2008 to 2010 applications was 23%
  • We abide by the AMRC’s principles of peer review

Key target areas for funding

The CGD Society funds research into the cause, inheritance, diagnosis, management and treatment of CGD. It is willing to consider research applications of high quality that address important scientific, clinical or social questions relating to CGD. The criteria for funding are excellent science and relevance to and benefit for CGD.

Priority research and scientific areas

The CGD Society is committed to providing funding in the following areas:

  • Gene and cellular therapy for CGD as a treatment and potential cure for CGD
  • Causes and treatment of inflammation in CGD. Understanding the mechanisms involved and improving treatment methods
  • Causes and treatment of infection in CGD. The mechanisms involved and improving methods of treatment
  • Basic research concerning the structure and function of the enzyme NADPH oxidase and identification of possible target pathways for therapeutic intervention

The Chronic Granulomatous Disorder Society is a member of the Association of Medical Research Charities (AMRC). All AMRC members support the AMRC position statement on the use of animals in research.

The grant application process

There is only one round of grant funding each year and a call for proposals is made in the journal 'Nature'.  Anyone interested in applying for a CGD research grant has to first complete a preliminary application. This gives details of the proposed work, its relevance to CGD and approximate costings for the work. These preliminary applications are reviewed by members of our medical panel and three lay reviewers from our Trustee board who rate the applications according to relevance to the charity’s research strategy and whether the science is likely to lead to benefit for the CGD community. At this stage approximately 30-50% of the applications are rejected. Successful applicants are then asked to submit a full application.

How we decide on funding

Three external independent experts with related research experience reviews each application. Independent experts are chosen that have no affiliation to the grant applications and are asked to declare any conflict of interest in being a reviewer before receiving an application. All reviewers are expected to respect the applicants' confidentiality. The CGDS provides guidance to the referees and supplies them a review form for this process. Peer reviewers are asked to score the applications on the basis of quality, relevance, originality, feasibility and value for money.

The Trust’s Medical and Scientific Advisory Panel consider the external reviewers' recommendations. The panel advises the Trust on the best quality research to fund and on setting priorities for future CGD research. We have in place a conflicts of interest policy and a register of interests for the CGD Society’s Medical and Scientific Advisory Panel by which all members agree to abide before joining the panel. Panel members can serve up to a maximum of six years on the panel.

The Association of Medical Research Charities approves all our peer review methods and in 2011 the CGD Society received a certificate of best practice for its peer review procedures.

Selecting the most promising projects

It is the nature of research that some avenues yield no useful results, but the CGDS is very careful where donors’ money is spent. Every application received is fully peer reviewed by external experts who pass on their advice to our dedicated Advisory Panel. This Panel then decides which projects would give the best scientific outcomes for CGD and the best value for money. Equally important, we demand absolute clarity regarding how grant funds were spent, and monitor and evaluate carefully.

CGDS: Our integrity

We are well connected with the biggest names in research in our field; with key hospitals, research establishments, scientists and medical professionals. We keep up a dialogue with other top bodies to maximise impact and avoid duplication of research. We are transparent and accountable, and are happy to provide details or exactly how research projects spent the money you gave us.

CGDS award categories

The CGD Society is disappointed to announce that there will not be a research grant round in 2011 or 2012

Project Grants

The purpose of these awards is to provide support for a time-limited project designed to answer a single question or a small group of related questions. Such questions must be directed towards furthering our understanding of CGD and/or developing effective treatments for the condition and that fit within the priority areas. Support is provided for up to two years. 

Innovative Basic Grant Awards

These are one-year grant awards to fund work that is fundamental to the understanding of CGD. Their aim is to provide support for a short-term, small-scale pilot or proof of concept research projects. Funds are available up to £40,000.

Ph.D. Studentships

Ph.D studentships are offered to exceptional candidates in laboratories that have a proven track record of research in CGD. The studentships are designed to encourage the best young science graduates to embark on a research career in CGD. Funds are available for up to £75,000 for three years.

Important notes for applicants

Before a full application can be considered the applicant(s) and the institution must sign a form stating that they will accept and adhere to the CGDS Terms and Conditions for Awards in the event of an award being made. Otherwise the application will not be considered. The CGDS will not enter into negotiation regarding this matter.

Please read our Notes for Applicants and our terms and conditions for awards before applying to the CGDS. Make sure your application is relevant to our research strategy.

Please use our checklist before you send the full application form.

Our Research Advisory Panel

Read more about our research advisory panel here

  • Professor Maggie Dallman, Principal of the Faculty of Natural Sciences and
  • Professor of Immunology at Imperial College London
  • Professor Len Seymour, Chair of Committee, Professor of Gene Therapies,
  • President of the British Society for Gene Therapy, University of Oxford
  • Professor Majlinda Lako, Professor of Stem Cell Science, Newcastle University,
  • Institute of Human Genetics, International Centre for Life, Newcastle upon Tyne
  • Professor Adriano Rossi, Chair of Respiratory and Inflammation Pharmacology at the University of Edinburgh/MRC Centre for Inflammation Research
  • Professor Tom Rogers, Head of Clinical Microbiology, Trinity College Dublin, St James's Hospital, Dublin
  • Dr Simon Travis, Clinical Director of Gastroenterology and Endoscopy, John Radcliffe Hospital, Oxford
  • Dr Roy Evison, retired GP
  • Professor Reinhard Seger, Consultant paediatrician, University Children's Hospital, Zurich
  • Professor Dirk Roos, Deptartment of Blood Cell Research, Sanquin Research Centre, Amsterdam
  • Andrew Orchard, CGDS Trustee

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IMPORTANT NOTE: The information contained on this website is intended only as a guideline, not as a substitute for medical advice. Always consult your doctor if you or your child has any CGD symptoms or concerns.