UK research study – colonoscopy versus MRI in CGD-associated colitis

The Royal Free Hospital in London is recruiting patients to a research study comparing the usefulness of colonoscopy with magnetic resonance imaging (MRI) in assessing CGD colitis.

The research study

The gut is frequently affected in CGD – usually as colitis (inflammation of the colon), which can cause diarrhoea, bleeding and pain. At the moment, doctors usually use colonoscopy to assess CGD colitis, but this is an invasive procedure.

More recently, MRI has been shown to be useful in studying bowel diseases. MRI scanning is a safe and non-invasive way of imaging the body and produces images of the bowel without using X-rays. It may be possible to use MRI scans to reliably tell how active CGD bowel disease is instead of colonoscopy, and this is what the study is trying to find out. Doctors will also look at whether simple clinical measurements, stool tests or blood tests can tell them about the activity of CGD colitis.

What is involved?

The study involves two visits to the Royal Free Hospital, which can be on consecutive days. On the first visit you will be examined by a doctor and asked some questions. Doctors will give you a ‘bowel prep’ for the colonoscopy and some pots for stool samples. On the second visit you will undergo a blood test, an MRI scan of your bowel and a colonoscopy. Doctors will compare the MRI scan with the results of the colonoscopy, and both investigations will be compared with your symptoms, blood test results and stool sample results. You will also be asked to complete questionnaires to help doctors establish which test (MRI or colonoscopy) patients prefer.

Who is eligible to take part?

To be eligible to take part you need to be at least 18 years old and have a confirmed diagnosis of CGD. You don’t need to have a diagnosis of colitis, but please note that you will not be able to participate if you have metal implants or are pregnant.

What expenses will be paid?

Your expenses to attend the Royal Free Hospital will be paid. Reasonable accommodation costs will be covered if appropriate.

Who to get in touch with?

If you would like to find out more, please contact Helen Braggins, the CGD Society clinical nurse specialist (, or Dr David Lowe (

Please note:

The CGD Society is advertising this study in cooperation with the Royal Free Hospital, London and has no liability regarding any adverse events that may result from patient participation.  Please talk through what is involved and the study’s risks and benefits carefully with the research team before giving informed consent.